Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 15/20 | 0.85 |
| ▸ | ADRA2C | P18825 | 14/20 | 0.85 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.85 |
| ▸ | ADRA1D | P25100 | 13/20 | 0.85 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028091 | 0.92 | ADRA2A (1.00) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Fumaric Acid SCHEMBL27521800 | 0.90 | ADRA2A (0.69) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| SCHEMBL1670164 | 0.78 | ADRA2A (0.59) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Brimonidine SCHEMBL24670 | 0.75 | ADRA2A (1.00) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Brimonidine SCHEMBL20511531 | 0.75 | ADRA2A (1.00) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| SCHEMBL29171467 | 0.75 | ADRA2A (1.00) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| SCHEMBL3353162 | 0.75 | ADRA2A (0.71) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Brimonidine SCHEMBL29374525 | 0.75 | ADRA2A (1.00) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Brimonidine SCHEMBL1685506 | 0.74 | ADRA2A (0.97) | ADRA2AADRA2CADRA2BADRA1DADRA1B | |
| Brimonidine SCHEMBL22616115 | 0.74 | ADRA2A (0.97) | ADRA2AADRA2CADRA2BADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944603-B1 | PROCESS FOR MAKING 2-AMINO-2-IMIDAZOLINE, GUANIDINE, AND 2-AMINO-3,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES | PROCTER & GAMBLE (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6066740-A | Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives | THE PROCTER & GAMBLE COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| EP-0944603-A1 | PROCESS FOR MAKING 2-AMINO-2-IMIDAZOLINE, GUANIDINE, AND 2-AMINO-3,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023595-A1 | PROCESS FOR MAKING 2-AMINO-2-IMIDAZOLINE, GUANIDINE, AND 2-AMINO-3,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |