Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656493 | 0.86 | CES2 (0.70) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL4721013 | 0.86 | CES2 (0.70) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL828959 | 0.84 | TSHR (0.69) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL7013007 | 0.83 | CES2 (0.66) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL31103641 | 0.83 | MEN1 (0.76) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL17297123 | 0.83 | TSHR (0.67) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL1572442 | 0.83 | MEN1 (0.76) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL3666192 | 0.83 | TSHR (0.67) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL27903047 | 0.83 | CES2 (0.66) | CES2CES1TP53TSHRALDH1A1 | |
| SCHEMBL19285363 | 0.83 | CES2 (0.66) | CES2CES1TP53TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |