SCHEMBL6965290

SCHEMBL6965290

COc1nc(C)c(C)cc1NC(=O)Oc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.48
GAA P10253 2/20 0.48
KDM4E B2RXH2 2/20 0.48
GLA P06280 1/20 0.48
HPGD P15428 1/20 0.48
ATM Q13315 1/20 0.48
KMT2A Q03164 4/20 0.47
HTT P42858 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
MEN1 O00255 2/20 0.46
TRPV1 Q8NER1 1/20 0.45
POLB P06746 1/20 0.45
MAOB P27338 1/20 0.45
MAPT P10636 2/20 0.43
CYP1A2 P05177 2/20 0.43
IDO1 P14902 1/20 0.42
FAAH O00519 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPK1 P28482 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27466605 1.00 ALDH1A1 (0.48) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6953240 0.86 KMT2A (0.46) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6965277 0.86 ALDH1A1 (0.48) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL8699311 0.85 ALDH1A1 (0.44) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6956452 0.85 ALDH1A1 (0.44) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6962164 0.84 MAPT (0.35) ALDH1A1GAAKDM4EKMT2AHTT
SCHEMBL6966654 0.83 ALDH1A1 (0.43) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6956239 0.83 ALDH1A1 (0.43) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6963709 0.83 KMT2A (0.48) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL6964824 0.82 ALDH1A1 (0.51) ALDH1A1GAAKDM4EGLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1152015-C Piperazine devivatives and process for preparation thereof ������ҩ��ʽ���� 2004-06-02 CN disclosed
EP-0850222-B1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARM CO LTD (KR) 2003-05-28 EP disclosed
US-6028195-A AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2000-02-22 US disclosed
CN-1196724-A Novel piperazine derivative and process for producing the same SAMJIN PHARM CO LTD (KR) 1998-10-21 CN disclosed
US-5780472-A ANTITUMOR AGENTS SAMJIN PHARMACEUTICAZL CO., LTD. (KR) 1998-07-14 US disclosed
EP-0850222-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 1998-07-01 EP disclosed
WO-1998000402-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1998-01-08 WO disclosed
EP-0749425-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARM. CO., LTD. (KR) 1996-12-27 EP disclosed
WO-1996021648-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1996-07-18 WO disclosed