Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 16/20 | 0.45 |
| ▸ | PLG | P00747 | 8/20 | 0.45 |
| ▸ | KLK1 | P06870 | 7/20 | 0.45 |
| ▸ | PLAT | P00750 | 6/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969685 | 0.83 | PLAU (0.49) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL5775243 | 0.72 | PLAU (0.46) | PLAUPLGKLK1PLATPRMT1 | |
| SCHEMBL5775238 | 0.72 | PLAU (0.46) | PLAUPLGKLK1PLATPRMT1 | |
| SCHEMBL5776489 | 0.65 | PLAU (0.66) | PLAUPLGKLK1PLATPRMT1 | |
| SCHEMBL5777924 | 0.65 | PLAU (0.66) | PLAUPLGKLK1PLATPRMT1 | |
| SCHEMBL5775530 | 0.64 | PLAU (0.66) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL5775525 | 0.64 | PLAU (0.66) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL6954311 | 0.64 | PLAU (0.48) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7333152 | 0.63 | PLAU (0.70) | PLAUPLGKLK1PLATPRMT1 | |
| SCHEMBL7342410 | 0.63 | PLAU (0.70) | PLAUPLGKLK1PLATPRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | claimed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | claimed |
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |