Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 19/20 | 0.49 |
| ▸ | PLG | P00747 | 12/20 | 0.49 |
| ▸ | KLK1 | P06870 | 11/20 | 0.49 |
| ▸ | PLAT | P00750 | 11/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965448 | 0.83 | PLAU (0.45) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL6954311 | 0.76 | PLAU (0.48) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL5773262 | 0.73 | PLAU (0.64) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL4312322 | 0.68 | PLAU (1.00) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL4312320 | 0.68 | PLAU (1.00) | PLAUPLGKLK1PLATF2 | |
| Hydrochloric Acid SCHEMBL7342777 | 0.68 | PLAU (0.69) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7340084 | 0.67 | PLAU (0.72) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7347108 | 0.67 | PLAU (0.72) | PLAUPLGKLK1PLATPRSS1 | |
| SCHEMBL5776002 | 0.66 | PLAU (0.65) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL5773569 | 0.66 | PLAU (0.58) | PLAUPLGKLK1PLATF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |