Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 4/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756420 | 0.75 | EPHX2 (0.45) | EPHX2MEN1KMT2AALDH1A1KLKB1 | |
| SCHEMBL696552 | 0.74 | SMN1; SMN2 (0.53) | EPHX2ALDH1A1LMNANPSR1KLKB1 | |
| SCHEMBL756846 | 0.68 | STIM1 (0.62) | EPHX2KDM4EALDH1A1LMNAKLKB1 | |
| SCHEMBL758944 | 0.68 | STIM1 (0.76) | EPHX2KDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL756919 | 0.68 | STIM1 (0.50) | EPHX2KDM4ELMNANPSR1KLKB1 | |
| SCHEMBL758485 | 0.68 | STIM1 (0.54) | EPHX2LMNANPSR1KLKB1 | |
| SCHEMBL761267 | 0.67 | STIM1 (0.49) | EPHX2KMT2AKDM4ELMNANPSR1 | |
| SCHEMBL755784 | 0.67 | STIM1 (0.61) | EPHX2ALDH1A1LMNANPSR1KLKB1 | |
| SCHEMBL760682 | 0.67 | STIM1 (0.54) | EPHX2KDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL1758329 | 0.67 | KDM1A (0.55) | KDM1AHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421835-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |