⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23528 | 0.82 | — | — | |
| SCHEMBL1547387 | 0.72 | — | — | |
| SCHEMBL10647334 | 0.69 | — | — | |
| SCHEMBL1705951 | 0.69 | — | — | |
| SCHEMBL6959697 | 0.67 | KCNA4 (0.37) | — | |
| SCHEMBL1564863 | 0.65 | — | — | |
| SCHEMBL9882834 | 0.63 | EPHX1 (0.32) | — | |
| SCHEMBL15255666 | 0.63 | — | — | |
| SCHEMBL6760749 | 0.63 | — | — | |
| SCHEMBL20504484 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | claimed |
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | claimed |
| EP-0636143-B1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | claimed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | claimed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | claimed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | claimed |
| US-5441960-A | 1-pyrimidinylacetamide human leukocyte elastate inhibitors | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | claimed |
| EP-0636144-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | claimed |
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | claimed |
| EP-0636141-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | claimed |
| EP-0636143-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | claimed |
| WO-1993021210-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | claimed |
| WO-1993021213-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | claimed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | claimed |
| WO-1993021214-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | claimed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | claimed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | claimed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | claimed |
| US-4536554-A | Hydrophilic polymers and contact lenses made therefrom | BARNES-HIND, INC. (US) | 1985-08-20 | — | — | US | claimed |
| WO-2024101411-A1 | CURABLE COMPOSITION FOR ORGANIC EL ELEMENTS, CURED PRODUCT FOR ORGANIC EL ELEMENTS AND METHOD FOR PRODUCING SAME, ORGANIC EL ELEMENT, AND POLYMER | JSR株式会社 | 2024-05-16 | — | — | WO | disclosed |
| CN-117590689-A | Radiation-sensitive composition, cured film, method for producing same, display device, and curable resin composition | JSR株式会社 | 2024-02-23 | — | — | CN | disclosed |
| CN-117148680-A | Radiation-sensitive composition, cured film, method for producing cured film, liquid crystal display device, and organic EL display device | JSR株式会社 | 2023-12-01 | — | — | CN | disclosed |
| WO-2023140248-A1 | METHOD FOR PRODUCING LENS, RADIATION-SENSITIVE COMPOSITION FOR PRODUCING LENS, LENS, IMAGING ELEMENT, IMAGING DEVICE, DISPLAY ELEMENT, AND DISPLAY DEVICE | JSR株式会社 | 2023-07-27 | — | — | WO | disclosed |
| CN-115963697-A | Radiation-sensitive composition, cured film, method for producing cured film, and display device | JSR株式会社 | 2023-04-14 | — | — | CN | disclosed |
| CN-115704995-A | Curable composition, cured film and application thereof, method for producing cured film, and polymer | JSR株式会社 | 2023-02-17 | — | — | CN | disclosed |
| CN-115268214-A | Radiation-sensitive composition, cured film and method for producing the same, semiconductor and display device | JSR株式会社 | 2022-11-01 | — | — | CN | disclosed |
| CN-115202152-A | Composition, cured film and method for producing same, semiconductor element, and display element | JSR株式会社 | 2022-10-18 | — | — | CN | disclosed |
| CN-113589647-A | Radiation-sensitive composition, method for producing cured film, semiconductor element, and display element | JSR株式会社 | 2021-11-02 | — | — | CN | disclosed |
| CN-113552769-A | Radiation-sensitive composition, cured film and method for producing same, semiconductor element, display element, and polymer | JSR株式会社 | 2021-10-26 | — | — | CN | disclosed |
| CN-113515024-A | Method for treating radiation-sensitive composition | JSR株式会社 | 2021-10-19 | — | — | CN | disclosed |
| US-20140045966-A1 | PHOTOSENSITIVE COMPOSITION. CURED ARTICLE, AND METHOD FOR PRODUCING ACTINICALLY CURED ARTICLE | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2014-02-13 | — | — | US | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| US-5736535-A | 1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 1998-04-07 | — | — | US | disclosed |
| US-5721222-A | Heterocyclic ketones | ZENECA LIMITED (GB) | 1998-02-24 | — | — | US | disclosed |
| EP-0636143-B1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| US-5486529-A | Certain pyridyl ketones for treating diseases involving leukocyte elastase | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| US-5441960-A | 1-pyrimidinylacetamide human leukocyte elastate inhibitors | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0636144-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636143-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636141-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021214-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| WO-1993021213-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| WO-1993021210-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |
| EP-0154270-A2 | Hydrophilic polymers and contact lenses made therefrom | Pilkington Visioncare, Inc. (a Delaware corp.) (US) | 1985-09-11 | — | — | EP | disclosed |
| US-4536554-A | Hydrophilic polymers and contact lenses made therefrom | BARNES-HIND, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4536554-A | Hydrophilic polymers and contact lenses made therefrom | BARNES-HIND, INC. (US) | 1985-08-20 | — | — | US | disclosed |