KCNA4

Potassium voltage-gated channel subfamily A member 4 · P22459 · KCNA4 on Sugi Atlas →

723 patent compounds predicted against KCNA4, 501 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13036733	1.00	9/20
Oroidin (SCHEMBL13036738)	1.00	9/20
Oroidin (SCHEMBL13036750)	1.00	9/20
SCHEMBL21182348	1.00	9/20
SCHEMBL13074094	0.74	9/20
SCHEMBL13036735	0.67	9/20
Clathrodin (SCHEMBL13036737)	0.67	9/20
Clathrodin (SCHEMBL13036741)	0.67	9/20
Oroidin (SCHEMBL12597862)	0.65	9/20
Oroidin (SCHEMBL14536687)	0.65	9/20
Oroidin (SCHEMBL28891358)	0.65	9/20
SCHEMBL31722801	0.64	9/20
Keramadine (SCHEMBL11123414)	0.64	9/20
Keramadine (SCHEMBL11123417)	0.64	9/20
SCHEMBL13036715	0.61	9/20
SCHEMBL13074314	0.52	9/20
SCHEMBL13074223	0.47	9/20
Hydrochloric Acid (SCHEMBL30045379)	0.55	4/20
SCHEMBL15228546	0.57	3/20
SCHEMBL15232609	0.57	3/20

Clinical trials — most relevant to KCNA4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes	PHASE4	UNKNOWN
Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)	PHASE2/PHASE3	RECRUITING
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
N-of-1 in ATS and MEPPC	PHASE2	NOT_YET_RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
SCN1A Horizons A Natural History Study of SCN1A-related Epilepsies in the United Kingdom	nan	RECRUITING
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias	nan	RECRUITING
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.	nan	NOT_YET_RECRUITING
Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a KCNA4 binder may also engage these)

Protein	Name	Similarity
Q28527	—	1.000	Q28527 →
Q05037	—	1.000	Q05037 →
Q61423	—	1.000	Q61423 →
P15385	—	0.999	P15385 →
P16390	—	0.999	P16390 →
P17659	—	0.997	P17659 →
P63141	—	0.996	P63141 →
P63142	—	0.996	P63142 →
Q28293	—	0.996	Q28293 →
Q16322	—	0.996	Q16322 →
P16388	—	0.995	P16388 →
P08510	—	0.995	P08510 →
KCNA3	Potassium voltage-gated channel subfamily A member 3	0.994	landscape →
Q7T199	—	0.994	Q7T199 →
P25122	—	0.994	P25122 →
Q63734	—	0.994	Q63734 →
Q9TUI4	—	0.992	Q9TUI4 →
Q03721	—	0.992	Q03721 →
P22462	—	0.992	P22462 →
KCNK3	Potassium channel subfamily K member 3	0.991	landscape →
KCNA2	Potassium voltage-gated channel subfamily A member 2	0.991	landscape →
P97414	—	0.991	P97414 →
P19024	—	0.990	P19024 →
Q3LS21	—	0.990	Q3LS21 →
P56698	—	0.990	P56698 →
P22739	—	0.990	P22739 →
KCNA1	Potassium voltage-gated channel subfamily A member 1	0.989	landscape →
P19334	—	0.989	P19334 →
Q9JL58	—	0.989	Q9JL58 →
P0C550	—	0.989	P0C550 →