Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | FAAH | O00519 | 2/20 | 0.64 |
| ▸ | ACHE | P22303 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271414 | 0.87 | CYP2C9 (0.77) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL24585221 | 0.85 | CYP2C9 (0.73) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL9272690 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL5272168 | 0.84 | KMT2A (1.00) | CYP2C9CYP2C19HPGDKMT2AALDH1A1 | |
| SCHEMBL6585055 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19KMT2AADAMTS5ALDH1A1 | |
| SCHEMBL9273340 | 0.83 | KMT2A (0.84) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL9271748 | 0.81 | KMT2A (0.82) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL9273628 | 0.81 | KMT2A (0.82) | CYP2C9CYP2C19HPGDKMT2AADAMTS5 | |
| SCHEMBL11316237 | 0.81 | MAPT (0.76) | CYP2C9CYP2C19KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL599832 | 0.81 | CYP2C9 (0.67) | CYP2C9CYP2C19KMT2AADAMTS5FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |