Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 1.00 |
| ▸ | HTR1B | P28222 | 16/20 | 1.00 |
| ▸ | DRD4 | P21917 | 3/20 | 0.73 |
| ▸ | DRD3 | P35462 | 3/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.72 |
| ▸ | HRH1 | P35367 | 3/20 | 0.72 |
| ▸ | MLNR | O43193 | 1/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7200289 | 0.92 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6966976 | 0.90 | HTR1A (0.85) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL7203413 | 0.88 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6960464 | 0.88 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL1135593 | 0.86 | HTR1A (0.86) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6966385 | 0.86 | HTR1A (0.84) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6599312 | 0.85 | HTR1B (0.77) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL7198949 | 0.85 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6960339 | 0.84 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL6962059 | 0.84 | HTR1A (1.00) | HTR1AHTR1BDRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |