SCHEMBL6966439

SCHEMBL6966439

CC(C)c1nc(CO)n(C)c1Sc1cccc([N+](=O)[O-])c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.41
HPGD P15428 4/20 0.38
LMNA P02545 4/20 0.38
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
GFER P55789 1/20 0.38
MAPT P10636 3/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
F2R P25116 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
F2RL3 Q96RI0 1/20 0.34
TSHR P16473 1/20 0.34
KDM4E B2RXH2 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
RECQL P46063 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964269 0.92 HSP90AA1 (0.39) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6972247 0.90 HSP90AA1 (0.38) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6962662 0.89 HSP90AA1 (0.41) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6956933 0.89 HSP90AA1 (0.41) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6972786 0.88 ALDH1A1 (0.42) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6967380 0.87 HSP90AA1 (0.39) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6967500 0.87 HSP90AA1 (0.39) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL7081854 0.87 HSP90AA1 (0.39) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL6961422 0.87 HSP90AA1 (0.39) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2
SCHEMBL7078920 0.87 ALDH1A1 (0.41) HSP90AA1HPGDLMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed