SCHEMBL6967592

SCHEMBL6967592

CCOC(=O)c1cccc(N2CCNCC2)n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.59
PRKCA P17252 2/20 0.51
PRKCQ Q04759 2/20 0.51
PRKCD Q05655 2/20 0.51
MAPT P10636 1/20 0.49
ALDH1A1 P00352 2/20 0.48
HTR3E A5X5Y0 1/20 0.48
HTR3B O95264 1/20 0.48
HTR3A P46098 1/20 0.48
HTR3D Q70Z44 1/20 0.48
HTR3C Q8WXA8 1/20 0.48
IRAK4 Q9NWZ3 1/20 0.47
KDM4E B2RXH2 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
KMT2A Q03164 2/20 0.46
GAA P10253 1/20 0.44
AOC3 Q16853 1/20 0.43
ADORA3 P0DMS8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL445411 0.99 CYP1A2 (0.57) CYP1A2PRKCAPRKCQPRKCDMAPT
SCHEMBL21875248 0.86 CYP1A2 (0.62) CYP1A2MAPTALDH1A1KDM4ENPC1
SCHEMBL28534611 0.85 CYP1A2 (0.60) CYP1A2PRKCQMAPTALDH1A1HTR3E
SCHEMBL2810512 0.84 CYP1A2 (0.59) CYP1A2MAPTALDH1A1IRAK4KDM4E
SCHEMBL19913879 0.83 PRKCQ (0.58) CYP1A2PRKCAPRKCQPRKCDMAPT
SCHEMBL441409 0.83 CYP1A2 (0.57) CYP1A2MAPTALDH1A1KDM4ENPC1
SCHEMBL6945432 0.82 CYP1A2 (0.56) CYP1A2PRKCQMAPTALDH1A1HTR3E
SCHEMBL31337804 0.82 CYP1A2 (0.56) CYP1A2MAPTALDH1A1KDM4ENPC1
SCHEMBL21612868 0.82 PRKCQ (0.51) CYP1A2PRKCAPRKCQPRKCDALDH1A1
SCHEMBL15347230 0.81 PRKCA (0.57) PRKCAPRKCQPRKCDALDH1A1HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2576539-A1 PYRIDINYLCARBOXYLIC ACID DERIVATIVES AS FUNGICIDES Bayer CropScience AG (DE) 2013-04-10 EP disclosed
WO-2011147765-A1 PYRIDINYLCARBOXYLIC ACID DERIVATIVES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2011-12-01 WO disclosed
EP-0934312-B1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK AS (DK) 2003-03-19 EP disclosed
CN-1088459-C 1,4-disubstituted piperazines NOVO NORDISK AS (DK) 2002-07-31 CN disclosed
US-6133268-A 1,4-disubstituted piperazines NOVO NORDISK A/S (DK) 2000-10-17 US disclosed
US-6040302-A ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY NOVO NORDISK A/S (DK) 2000-03-21 US disclosed
US-6004961-A ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES NOVO NORDISK A/S (DK) 1999-12-21 US disclosed
CN-1234799-A 1,4-disubstituted piperazines NOVO NORDISK AS (DK) 1999-11-10 CN disclosed
EP-0934312-A1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK A/S (DK) 1999-08-11 EP disclosed
US-5916889-A ANTIDIABETIC AGENT; DIETETICS NOVO NORDISK A/S (DK) 1999-06-29 US disclosed
WO-1998015548-A1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK A/S (DK) 1998-04-16 WO disclosed