Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 5/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129551 | 0.80 | APP (0.70) | HTR2CADRB2APPNMT2NMT1 | |
| SCHEMBL17365461 | 0.72 | APP (0.70) | HTR2CADRB2APPHTR1ANMT2 | |
| SCHEMBL22491588 | 0.72 | APP (0.54) | HTR2CADRB2APPHTR6HTR2A | |
| SCHEMBL22491479 | 0.71 | APP (0.48) | HTR2CADRB2APPHTR6HTR2A | |
| SCHEMBL7216288 | 0.71 | OPRL1 (0.48) | HTR2CHTR6HTR1AHTR2A | |
| SCHEMBL7482397 | 0.71 | HTR1D (0.68) | HTR2CADRB2APPHTR6HTR1D | |
| SCHEMBL21089078 | 0.71 | HTR2C (0.62) | HTR2CADRB2APPHTR6HTR1D | |
| SCHEMBL2781509 | 0.71 | HTR2C (0.62) | HTR2CADRB2APPHTR6HTR1B | |
| SCHEMBL7459828 | 0.71 | HTR2C (0.62) | HTR2CADRB2APPHTR6HTR1D | |
| SCHEMBL3549500 | 0.71 | CYP1A2 (0.68) | HTR2CADRB2APPHTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| CN-1047385-C | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1999-12-15 | — | — | CN | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |