Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22491588 | 0.82 | APP (0.54) | APPHTR2CADRB2NMT2NMT1 | |
| SCHEMBL22491597 | 0.74 | MAPT (0.44) | — | |
| SCHEMBL4675208 | 0.73 | HTR2C (0.62) | APPHTR2CADRB2HTR6SLC6A4 | |
| SCHEMBL2781047 | 0.73 | HTR2C (0.62) | APPHTR2CADRB2NMT2NMT1 | |
| SCHEMBL6967690 | 0.71 | HTR2C (0.53) | APPHTR2CADRB2NMT2NMT1 | |
| Hydrochloric Acid SCHEMBL7867871 | 0.71 | HTR2C (0.63) | APPHTR2CADRB2HTR6SLC6A4 | |
| Hydrochloric Acid SCHEMBL893002 | 0.71 | HTR2C (0.63) | APPHTR2CADRB2NMT2NMT1 | |
| SCHEMBL2781509 | 0.70 | HTR2C (0.62) | APPHTR2CADRB2NMT2NMT1 | |
| SCHEMBL30275187 | 0.70 | HTR2A (0.64) | APPHTR2CADRB2NMT2NMT1 | |
| SCHEMBL2904310 | 0.70 | HTR2A (0.64) | APPHTR2CADRB2NMT2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717477-A1 | NEW HETEROCYCLIC COMPOUNDS | H. Hoffnabb-La Roche Ag (CH) | 2020-10-07 | — | — | EP | disclosed |