Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.64 |
| ▸ | TEK | Q02763 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.91 | IGF1R (0.79) | IGF1RAURKAFAM20CKDREGFR | |
| SCHEMBL6980742 | 0.89 | FAM20C (0.78) | IGF1RFAM20CKDREGFRCDK2 | |
| SCHEMBL31180291 | 0.88 | IGF1R (0.71) | IGF1RAURKAFAM20CKDREGFR | |
| SCHEMBL6981464 | 0.87 | IGF1R (0.78) | IGF1RAURKABRAFFAM20CKDR | |
| SCHEMBL6976835 | 0.87 | IGF1R (0.78) | IGF1RAURKAFAM20CKDREGFR | |
| SCHEMBL6979468 | 0.85 | IGF1R (0.64) | IGF1RAURKAFAM20CKDREGFR | |
| SCHEMBL1116426 | 0.85 | IGF1R (0.74) | IGF1RFAM20CKDREGFRCDK2 | |
| SCHEMBL1116441 | 0.83 | IGF1R (0.76) | IGF1RAURKABRAFFAM20CKDR | |
| SCHEMBL6968704 | 0.83 | IGF1R (0.65) | IGF1RFAM20CKDREGFRCDK2 | |
| SCHEMBL6965131 | 0.83 | IGF1R (0.62) | IGF1RAURKAFAM20CKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | claimed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | claimed |
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |