SCHEMBL6967919

SCHEMBL6967919

Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1NC(=O)c1ccc(CN2CCOCC2)cc1

nearest known ligand 0.68

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.68
MAPK13 O15264 1/20 0.59
HSPB1 P04792 1/20 0.59
MAPK12 P53778 1/20 0.59
MAPK11 Q15759 1/20 0.59
RAF1 P04049 1/20 0.56
BRAF P15056 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7840747 0.93 MAPK14 (0.70) MAPK14RAF1BRAF
SCHEMBL7680447 0.92 MAPK14 (0.69) MAPK14MAPK13HSPB1MAPK12MAPK11
SCHEMBL6968456 0.92 MAPK14 (0.66) MAPK14MAPK13HSPB1MAPK12MAPK11
SCHEMBL6978368 0.90 MAPK14 (0.61) MAPK14MAPK13HSPB1MAPK12MAPK11
SCHEMBL6975166 0.87 MAPK14 (0.65) MAPK14MAPK13HSPB1MAPK12MAPK11
SCHEMBL6980707 0.87 MAPK14 (0.67) MAPK14MAPK13HSPB1MAPK12MAPK11
SCHEMBL6968243 0.87 MAPK14 (0.61) MAPK14RAF1BRAF
SCHEMBL5897801 0.86 MAPK14 (0.79) MAPK14MAPK13RAF1BRAF
SCHEMBL6974560 0.86 MAPK14 (0.60) MAPK14RAF1BRAF
SCHEMBL5897136 0.85 MAPK14 (0.75) MAPK14RAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115707-B1 BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS ASTRAZENECA AB (SE) 2003-11-12 EP claimed
US-6455520-B1 TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS ASTRA ZENECA AB (SE) 2002-09-24 US claimed
EP-1115707-B1 BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS ASTRAZENECA AB (SE) 2003-11-12 EP disclosed
US-6455520-B1 TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS ASTRA ZENECA AB (SE) 2002-09-24 US disclosed
EP-1115707-A1 BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS AstraZeneca AB (SE) 2001-07-18 EP disclosed
WO-2000018738-A1 BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS ASTRAZENECA AB (SE) 2000-04-06 WO disclosed