Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980077 | 0.90 | MAPK14 (0.55) | MAPK14 | |
| SCHEMBL6966955 | 0.90 | MAPK14 (0.67) | MAPK14 | |
| SCHEMBL6967919 | 0.87 | MAPK14 (0.68) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL5897180 | 0.85 | MAPK14 (0.73) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL7834857 | 0.85 | MAPK14 (0.69) | MAPK14 | |
| SCHEMBL7680447 | 0.84 | MAPK14 (0.69) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL5897793 | 0.83 | MAPK14 (0.65) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL6977319 | 0.83 | MAPK14 (0.64) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL6975166 | 0.82 | MAPK14 (0.65) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL5897136 | 0.82 | MAPK14 (0.75) | MAPK14RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | claimed |
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |