Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980253 | 0.88 | SRC (0.53) | SRCKDREGFR | |
| Hydrochloric Acid SCHEMBL3276171 | 0.84 | SRC (0.70) | SRCKDREGFRERBB2 | |
| SCHEMBL3280155 | 0.81 | SRC (0.72) | SRCKDR | |
| SCHEMBL3274592 | 0.80 | SRC (0.68) | SRCKDREGFR | |
| SCHEMBL3283205 | 0.79 | SRC (0.84) | SRCKDR | |
| SCHEMBL3276987 | 0.79 | SRC (0.72) | SRCKDREGFR | |
| SCHEMBL3279574 | 0.79 | SRC (0.64) | SRCKDREGFRERBB2 | |
| SCHEMBL3281554 | 0.78 | SRC (0.72) | SRCKDREGFR | |
| SCHEMBL3274435 | 0.78 | SRC (0.61) | SRCKDREGFRERBB2 | |
| SCHEMBL3206798 | 0.76 | SRC (0.54) | SRCKDREGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |