Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.53 |
| ▸ | KDR | P35968 | 10/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968068 | 0.88 | SRC (0.53) | SRCKDREGFR | |
| SCHEMBL3282453 | 0.79 | SRC (0.73) | SRCKDR | |
| SCHEMBL3276140 | 0.77 | SRC (0.86) | SRCKDR | |
| SCHEMBL3276553 | 0.77 | SRC (0.69) | SRCKDREGFR | |
| SCHEMBL3279077 | 0.76 | SRC (0.77) | SRCKDREGFR | |
| SCHEMBL3280052 | 0.76 | SRC (0.67) | SRCKDREGFRRETKIF5B | |
| SCHEMBL3275923 | 0.74 | SRC (0.70) | SRCKDREGFR | |
| SCHEMBL3282736 | 0.74 | SRC (0.57) | SRCKDREGFRRETKIF5B | |
| SCHEMBL3282155 | 0.72 | SRC (0.55) | SRCKDREGFR | |
| SCHEMBL3274759 | 0.72 | SRC (0.77) | SRCKDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |