Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12523828 | 0.92 | P2RX7 (0.43) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL28701145 | 0.86 | ADORA1 (0.38) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL4005175 | 0.86 | NR1H2 (0.41) | NR1H2USP2SMN1; SMN2ESR2ALDH1A1 | |
| SCHEMBL1583253 | 0.86 | P2RX7 (0.46) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL28705739 | 0.85 | MAPK1 (0.38) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL24744821 | 0.84 | NR1H2 (0.40) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL1176507 | 0.84 | NR1H2 (0.40) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL4390630 | 0.84 | NR1H2 (0.41) | NR1H2USP2SMN1; SMN2ESR2ALDH1A1 | |
| SCHEMBL19034775 | 0.84 | P2RX7 (0.38) | P2RX7NR1H2USP2SMN1; SMN2ESR2 | |
| SCHEMBL1583540 | 0.83 | CNR2 (0.40) | P2RX7NR1H2USP2SMN1; SMN2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882041-B1 | PIPERAZINONEPHENYLOXAZOLIDINONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| US-6069145-A | AGAINST ANTIBIOTIC RESISTANT BACTERIA | ZENECA LIMITED (GB) | 2000-05-30 | — | — | US | disclosed |
| EP-0882041-A1 | PIPERAZINONEPHENYLOXAZOLIDINONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997027188-A1 | PIPERAZINONEPHENYLOXAZOLIDINONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ZENECA LIMITED (GB) | 1997-07-31 | — | — | WO | disclosed |