Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 15/20 | 0.63 |
| ▸ | PLG | P00747 | 8/20 | 0.45 |
| ▸ | PLAT | P00750 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6964761 | 0.97 | PLAU (0.64) | PLAUPLGPLATALDH1A1LMNA | |
| SCHEMBL6437267 | 0.95 | PLAU (0.69) | PLAUPLGPLATALDH1A1LMNA | |
| SCHEMBL6433534 | 0.90 | PLAU (0.56) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL7373055 | 0.90 | PLAU (0.56) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6433537 | 0.90 | PLAU (0.56) | PLAUPLGPLATALDH1A1 | |
| Hydrochloric Acid SCHEMBL6434303 | 0.89 | PLAU (0.55) | PLAUPLGPLATALDH1A1 | |
| Hydrochloric Acid SCHEMBL6433796 | 0.89 | PLAU (0.55) | PLAUPLGPLATALDH1A1 | |
| Hydrochloric Acid SCHEMBL6433802 | 0.89 | PLAU (0.55) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6435153 | 0.85 | PLAU (0.52) | PLAUPLGPLAT | |
| SCHEMBL7378283 | 0.85 | PLAU (0.52) | PLAUPLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER (US) | 2003-01-08 | — | — | EP | claimed |