SCHEMBL6969430

SCHEMBL6969430

COc1ccc(C=C2Oc3cc(OC(=O)c4ccccc4)ccc3C2=O)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.77
MEN1 O00255 3/20 0.77
USP2 O75604 3/20 0.77
KMT2A Q03164 3/20 0.77
BCL2L1 Q07817 1/20 0.77
MCL1 Q07820 1/20 0.77
MAOB P27338 3/20 0.70
NPC1 O15118 2/20 0.65
RAB9A P51151 2/20 0.65
KIT P10721 1/20 0.65
KDM4E B2RXH2 2/20 0.63
MAPT P10636 2/20 0.63
TDP1 Q9NUW8 2/20 0.63
PLIN1 O60240 1/20 0.63
TNNI3 P19429 1/20 0.63
TNNT2 P45379 1/20 0.63
TNNC1 P63316 1/20 0.63
PLIN5 Q00G26 1/20 0.63
ABHD5 Q8WTS1 1/20 0.63
ACHE P22303 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6969428 1.00 ALDH1A1 (0.77) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6967035 0.93 ALDH1A1 (0.72) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6967040 0.93 ALDH1A1 (0.72) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6968912 0.91 MEN1 (0.70) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6968908 0.91 MEN1 (0.70) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6966053 0.90 CSNK2A2 (0.69) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6966060 0.90 CSNK2A2 (0.69) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6970226 0.88 ALDH1A1 (0.66) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6970225 0.88 ALDH1A1 (0.66) ALDH1A1MEN1USP2KMT2ABCL2L1
SCHEMBL6427555 0.84 MAOB (0.84) MEN1KMT2AMAOBNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0902022-B1 NOVEL BENZOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME DAIICHI SEIYAKU CO (JP) 2003-07-30 EP disclosed
US-6143779-A Benzofuranone derivatives and a method for producing them SNOW BRAND MILK PRODUCTS CO., LTD. (JP) 2000-11-07 US disclosed
EP-0902022-A1 NOVEL BENZOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME SNOW BRAND MILK PRODUCTS CO., LTD. (JP) 1999-03-17 EP disclosed