Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972156 | 0.86 | XDH (0.70) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL29310490 | 0.81 | GSK3B (0.79) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL6974659 | 0.79 | XDH (0.46) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL4822785 | 0.77 | GSK3B (0.84) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL2403432 | 0.75 | XDH (1.00) | XDHSMN1; SMN2GSK3B | |
| SCHEMBL4643669 | 0.75 | GSK3B (0.72) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL6977099 | 0.73 | XDH (0.72) | XDHSMN1; SMN2MAPK1ALDH1A1KDM4E | |
| SCHEMBL14072013 | 0.72 | XDH (0.60) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL28132422 | 0.72 | GSK3B (0.70) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 | |
| SCHEMBL14080308 | 0.71 | XDH (0.58) | XDHSMN1; SMN2GSK3BMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |