Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.50 |
| ▸ | DRD2 | P14416 | 9/20 | 0.50 |
| ▸ | DRD3 | P35462 | 9/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.50 |
| ▸ | DRD4 | P21917 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 4/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501183 | 0.78 | HTR2A (0.43) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL13051501 | 0.77 | HTR2A (0.78) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| Water SCHEMBL6969320 | 0.73 | DRD2 (0.42) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL3749292 | 0.71 | HTR2A (0.68) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL7980463 | 0.71 | HTR2A (0.68) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL13867587 | 0.71 | HTR2A (0.68) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL13522139 | 0.71 | HTR2A (0.68) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL6961973 | 0.71 | HTR2A (0.68) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| Didesmethylimipramine SCHEMBL10376169 | 0.71 | HTR2A (1.00) | HTR2ACHRM2CHRM1CHRM3DRD2 | |
| SCHEMBL14140510 | 0.70 | HTR2A (0.62) | HTR2ACHRM2CHRM1CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820451-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | claimed |