Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973318 | 0.95 | MAPK14 (0.38) | MAPK14MEN1KMT2AHDAC1HDAC8 | |
| SCHEMBL6974514 | 0.95 | MEN1 (0.35) | MEN1KMT2AHDAC1HDAC8CYP2C9 | |
| SCHEMBL6965421 | 0.92 | POLB (0.38) | MAPK14MEN1KMT2ATSSK1BALDH1A1 | |
| SCHEMBL7084584 | 0.91 | MAPK14 (0.37) | MAPK14GSK3B | |
| SCHEMBL7079248 | 0.90 | TDP1 (0.37) | GSK3BALDH1A1TDP1 | |
| SCHEMBL7080045 | 0.89 | MEN1 (0.37) | MEN1KMT2ACYP2C9ALDH1A1TP53 | |
| SCHEMBL6972978 | 0.88 | MEN1 (0.35) | MEN1KMT2AHDAC1HDAC8TSSK1B | |
| SCHEMBL7082887 | 0.87 | GCGR (0.33) | MEN1KMT2AHDAC1HDAC8ALDH1A1 | |
| SCHEMBL6966608 | 0.86 | MAPK14 (0.37) | MAPK14GSK3B | |
| SCHEMBL6961438 | 0.86 | MAPK14 (0.34) | MAPK14GSK3BALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |