Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 8/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644972 | 1.00 | CDK1 (1.00) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL29819445 | 0.89 | KDR (1.00) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL6968182 | 0.89 | KDR (1.00) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL30583253 | 0.88 | CDK1 (0.78) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL4996872 | 0.88 | CDK1 (0.78) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL7089728 | 0.87 | NPC1 (0.81) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL6969359 | 0.84 | KDR (0.74) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL7092553 | 0.84 | CDK1 (0.71) | CDK1CDK2KDRCHEK1NPC1 | |
| SCHEMBL7000053 | 0.84 | CHEK1 (0.97) | CDK1CDK2KDRCHEK1 | |
| SCHEMBL6967709 | 0.84 | KDR (0.78) | CDK1CDK2KDRCHEK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023063-B1 | INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2003-09-10 | — | — | EP | disclosed |
| US-6451834-B1 | Indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-17 | — | — | US | disclosed |
| EP-1023063-A1 | INDENO 1,2-c]-, NAPHTHO 1,2-c]- AND BENZO 6,7]CYCLOHEPTA 1,2-c]PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999017769-A1 | INDENO[1,2-c]-, NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |