Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974012 | 0.95 | PDE4A (0.38) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6963024 | 0.91 | PDE4A (0.39) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6973612 | 0.91 | KMT2A (0.39) | KMT2AMEN1MAPTL3MBTL1HPGD | |
| SCHEMBL6970666 | 0.90 | PDE4A (0.38) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6965153 | 0.89 | PDE4A (0.37) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6965158 | 0.89 | PDE4A (0.37) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL7083804 | 0.88 | PDE4A (0.36) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6973302 | 0.88 | MEN1 (0.35) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL6965427 | 0.88 | PDE4A (0.39) | PDE4AKMT2AMEN1PDE4DPDE4B | |
| SCHEMBL7082403 | 0.87 | HSP90AA1 (0.36) | KMT2AMEN1MAPTHPGDGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |