Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 4/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961379 | 0.91 | GAA (0.43) | GHSRACEF2RL1MTNR1BKDM4E | |
| SCHEMBL6974862 | 0.87 | ACE (0.40) | ACEF2RL1MTNR1BTSHR | |
| SCHEMBL6970316 | 0.82 | MTNR1B (0.40) | ACEF2RL1MTNR1BMTNR1A | |
| SCHEMBL6962527 | 0.80 | ACE (0.40) | ACEF2RL1MTNR1B | |
| SCHEMBL6974443 | 0.79 | ACE (0.38) | ACEF2RL1MTNR1B | |
| SCHEMBL6972820 | 0.79 | MEN1 (0.41) | GHSRACEMTNR1BALDH1A1 | |
| SCHEMBL2848460 | 0.78 | GRM2 (0.37) | ACEMTNR1BMTNR1AKDM4E | |
| SCHEMBL6974568 | 0.78 | ACE (0.39) | ACEF2RL1KDM4EALDH1A1 | |
| SCHEMBL6961296 | 0.77 | ACE (0.46) | GHSRACEMTNR1BTSHR | |
| SCHEMBL6961368 | 0.76 | ACE (0.35) | ACEF2RL1MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |