Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 14/20 | 0.67 |
| ▸ | CDK2 | P24941 | 14/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963391 | 1.00 | CCNE1 (0.67) | CCNE1CDK2CCNE2PDPK1RET | |
| SCHEMBL6957524 | 0.86 | CCNE1 (0.71) | CCNE1CDK2CCNE2PDPK1RET | |
| SCHEMBL6957516 | 0.86 | CCNE1 (0.71) | CCNE1CDK2CCNE2PDPK1RET | |
| SCHEMBL6965075 | 0.85 | CCNE1 (0.67) | CCNE1CDK2CCNE2PDPK1 | |
| SCHEMBL6965082 | 0.85 | CCNE1 (0.67) | CCNE1CDK2CCNE2PDPK1 | |
| SCHEMBL6966246 | 0.82 | CDK2 (0.76) | CCNE1CDK2CCNE2PDPK1RET | |
| SCHEMBL6966253 | 0.82 | CDK2 (0.76) | CCNE1CDK2CCNE2PDPK1RET | |
| SCHEMBL5477365 | 0.80 | CCNE1 (0.76) | CCNE1CDK2CCNE2RET | |
| SCHEMBL5477361 | 0.80 | CCNE1 (0.76) | CCNE1CDK2CCNE2RET | |
| SCHEMBL6963470 | 0.78 | PDPK1 (0.76) | PDPK1RETCHEK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | claimed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | claimed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |