SCHEMBL6970922

SCHEMBL6970922

CCCCC(=O)[N]C(=O)C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.44
CES2 O00748 5/20 0.44
ALDH1A1 P00352 3/20 0.41
TP53 P04637 1/20 0.41
CA1 P00915 1/20 0.39
LMNA P02545 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
FAAH O00519 1/20 0.36
MAPK1 P28482 1/20 0.36
AKR1B1 P15121 1/20 0.36
PPARG P37231 3/20 0.34
PPARD Q03181 3/20 0.34
PPARA Q07869 3/20 0.34
TSHR P16473 2/20 0.34
GPR84 Q9NQS5 2/20 0.34
HDAC11 Q96DB2 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
SLC22A6 Q4U2R8 1/20 0.34
SLC22A8 Q8TCC7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6962993 0.88 CES2 (0.38) CES1CES2ALDH1A1TP53LMNA
SCHEMBL543757 0.83 CES1 (0.55) CES1CES2ALDH1A1TP53CA1
SCHEMBL7059217 0.78 TDP1 (0.32) ALDH1A1TDP1
SCHEMBL6961963 0.78 CES1 (0.50) CES1CES2ALDH1A1TP53CA1
SCHEMBL6977331 0.76 CES1 (0.48) CES1CES2ALDH1A1TP53CA1
SCHEMBL9560717 0.76 CES1 (0.48) CES1CES2ALDH1A1TP53CA1
SCHEMBL6969726 0.76 CES1 (0.48) CES1CES2ALDH1A1TP53CA1
SCHEMBL175600 0.75 CES2 (0.57) CES1CES2ALDH1A1MEN1KMT2A
SCHEMBL7312353 0.74 CES1 (0.46) CES1CES2ALDH1A1TP53CA1
SCHEMBL10954355 0.73 CES2 (0.59) CES1CES2ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0870765-B1 AMINOTHIAZOLE DERIVATIVES, DRUG CONTAINING THE SAME AND INTERMEDIATE IN THE PRODUCTION OF THE COMPOUNDS ZERIA PHARM CO LTD (JP) 2003-11-19 EP disclosed
EP-0994108-B1 PROCESS FOR PRODUCING 2-HYDROXYBENZAMIDE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-05-14 EP disclosed
US-6197970-B1 REACTING WITH SECONDARY OR TERTIARY AMINE; DEBLOCKING, DEPROTECTING ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0994108-A1 PROCESS FOR PRODUCING 2-HYDROXYBENZAMIDE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 2000-04-19 EP disclosed
US-5981557-A HAVING IMPROVING EFFECTS ON THE DYSMOTILITY IN THE GASTROINTESTINAL TRACT ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-11-09 US disclosed
EP-0870765-A1 AMINOTHIAZOLE DERIVATIVES, DRUG CONTAINING THE SAME AND INTERMEDIATE IN THE PRODUCTION OF THE COMPOUNDS ZERIA PHARMACEUTICAL CO., LTD. (JP) 1998-10-14 EP disclosed