Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THPO | P40225 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9273786 | 0.88 | GAA (0.49) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8563763 | 0.87 | NPSR1 (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8556344 | 0.87 | NPSR1 (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL7885518 | 0.84 | GAA (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL1368071 | 0.81 | GAA (1.00) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9266525 | 0.81 | GAA (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9266460 | 0.81 | GAA (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8559691 | 0.80 | GAA (0.41) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9399943 | 0.78 | EGFR (0.52) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9266843 | 0.77 | GAA (0.61) | NPSR1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3997401-A | Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine | G. D. SEARLE & CO. (US) | 1976-12-14 | — | — | US | claimed |
| EP-0911331-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-0694546-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and use | SEARLE & CO (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-0583421-B1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0911331-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0512400-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0696283-B1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5604220-A | ANALGESICS, PROSTAGLANDIN E ANTAGONIST | G. D. SEARLE & COMPANY (US) | 1997-02-18 | — | — | US | disclosed |
| WO-1992019605-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G. D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| WO-1992019617-A2 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512399-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0512400-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0480641-A1 | Tricyclic heterocycles | ZENECA LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-4086268-A | 2-(2-Amino-4-chlorophenoxy)benzyl alcohol and diacetate derivative | G. D. SEARLE & CO. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4086268-A | 2-(2-Amino-4-chlorophenoxy)benzyl alcohol and diacetate derivative | G. D. SEARLE & CO. (US) | 1978-04-25 | — | — | US | disclosed |
| US-3997401-A | Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine | G. D. SEARLE & CO. (US) | 1976-12-14 | — | — | US | disclosed |
| US-3997401-A | Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine | G. D. SEARLE & CO. (US) | 1976-12-14 | — | — | US | disclosed |
| US-3997401-A | Microbial transformation of 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine | G. D. SEARLE & CO. (US) | 1976-12-14 | — | — | US | disclosed |