Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | THPO | P40225 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970933 | 0.87 | NPSR1 (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL7885518 | 0.87 | GAA (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8563763 | 0.84 | NPSR1 (0.67) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL1368071 | 0.81 | GAA (1.00) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8562293 | 0.78 | GAA (0.40) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9273786 | 0.75 | GAA (0.49) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL8725779 | 0.74 | ALOX5 (0.65) | NPSR1GAAMAPTAHRHTR2B | |
| SCHEMBL8813832 | 0.74 | MAOA (0.65) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL30587831 | 0.74 | MAOA (0.65) | NPSR1GAAMAPTMEN1KMT2A | |
| SCHEMBL9853243 | 0.72 | GAA (0.69) | NPSR1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5317101-A | Antihyperalgesics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-05-31 | — | — | US | disclosed |
| US-5189033-A | Analgesics, antiiflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| EP-0480641-A1 | Tricyclic heterocycles | ZENECA LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |