Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | TKT | P29401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450908 | 0.83 | NR1H2 (0.45) | NR1H2DAONPC1RAB9A | |
| SCHEMBL2868952 | 0.78 | NR1H2 (0.45) | NR1H2NOTUMMAPTPRNPDAO | |
| SCHEMBL2872354 | 0.74 | NR1H2 (0.49) | NR1H2MAPTPRNPNPC1LMNA | |
| SCHEMBL2865654 | 0.74 | NR1H2 (0.39) | NR1H2MAPTPRNPHSP90AB1DAO | |
| SCHEMBL23778736 | 0.74 | NOTUM (0.45) | NR1H2NOTUMMAPTNPC1RAB9A | |
| SCHEMBL3099997 | 0.73 | — | — | |
| SCHEMBL3840210 | 0.72 | HSP90AB1 (0.45) | MAPTPRNPHSP90AB1DAONPC1 | |
| SCHEMBL11291862 | 0.72 | TAAR1 (0.49) | — | |
| SCHEMBL2871695 | 0.72 | NR1H2 (0.40) | NR1H2MAPTPRNPHSP90AB1LMNA | |
| SCHEMBL2872342 | 0.72 | GAA (0.51) | NR1H2NOTUMMAPTPRNPDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |