Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139810 | 0.84 | ALDH1A1 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1MAPT | |
| SCHEMBL15385 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL1501319 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL10715347 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL669388 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL608814 | 0.80 | ABL1 (0.68) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL11069437 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL6790464 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL6790467 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 | |
| SCHEMBL28924800 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-20030114449-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2003-06-19 | — | — | US | disclosed |
| EP-1255756-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |