Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 13/20 | 0.49 |
| ▸ | FLT1 | P17948 | 12/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.49 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | FLT4 | P35916 | 7/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446461 | 0.80 | EPHA2 (0.79) | EPHA2EPHB4KDRFLT1FGFR1 | |
| SCHEMBL6478625 | 0.79 | EGFR (0.51) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL3692729 | 0.77 | FGFR1 (0.49) | EPHA2KDRFLT1FGFR1EGFR | |
| Hydrochloric Acid SCHEMBL7086434 | 0.76 | EGFR (0.43) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7797258 | 0.74 | KDR (0.59) | EPHA2EPHB4KDRFLT1FGFR1 | |
| SCHEMBL3668398 | 0.73 | EGFR (0.69) | EPHA2EPHB4KDRFLT1FGFR1 | |
| SCHEMBL7791030 | 0.73 | FLT1 (0.55) | KDRFLT1FGFR1EGFRCSF1R | |
| SCHEMBL3677683 | 0.70 | KDR (0.45) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7801861 | 0.70 | KDM4E (0.55) | KDRFLT1EGFRSRCCSF1R | |
| SCHEMBL4674469 | 0.70 | DRD4 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274692-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001077085-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-18 | — | — | WO | disclosed |