Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.59 |
| ▸ | EGFR | P00533 | 13/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | KIF5B | P33176 | 2/20 | 0.59 |
| ▸ | FLT1 | P17948 | 12/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.46 |
| ▸ | FLT4 | P35916 | 10/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478589 | 0.91 | KDR (0.49) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL4780880 | 0.84 | EGFR (0.49) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL3668398 | 0.84 | EGFR (0.69) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL7791030 | 0.84 | FLT1 (0.55) | KDREGFRFLT1FGFR1FGFR2 | |
| SCHEMBL7766729 | 0.79 | MEN1 (0.46) | KDREGFRPDGFRBERBB2LCK | |
| SCHEMBL7797381 | 0.79 | KDM4E (0.43) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL7799235 | 0.79 | CSF1R (0.52) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL7790969 | 0.79 | EGFR (0.55) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL7595199 | 0.78 | PDGFRB (0.43) | KDREGFRRETKIF5BFGFR1 | |
| SCHEMBL5446668 | 0.78 | RAF1 (0.50) | KDREGFRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |