Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 5/20 | 0.49 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 8/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969594 | 0.96 | TRAP1 (0.49) | TRAP1HSP90B1MAOBALDH1A1MAOA | |
| SCHEMBL6969499 | 0.93 | TRAP1 (0.51) | TRAP1HSP90B1MAOBBCHEACHE | |
| SCHEMBL6970454 | 0.93 | TRAP1 (0.51) | TRAP1HSP90B1MAOBBCHEACHE | |
| SCHEMBL6967469 | 0.93 | TRAP1 (0.47) | TRAP1HSP90B1MAOBBCHEACHE | |
| SCHEMBL6967371 | 0.92 | BCHE (0.52) | TRAP1HSP90B1MAOBBCHEACHE | |
| SCHEMBL6970191 | 0.89 | TRAP1 (0.51) | TRAP1HSP90B1MAOBBCHEACHE | |
| SCHEMBL6969597 | 0.89 | TRAP1 (0.51) | TRAP1HSP90B1MAOBMAOAHSP90AA1 | |
| SCHEMBL6967448 | 0.89 | TRAP1 (0.46) | TRAP1HSP90B1MAOBMAOAPDE3B | |
| SCHEMBL6972778 | 0.88 | TRAP1 (0.49) | TRAP1HSP90B1MAOBHRH3HSP90AA1 | |
| SCHEMBL6971719 | 0.88 | TRAP1 (0.50) | TRAP1HSP90B1MAOBBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | HSP90AB1, HSP90AA1, HSP90AB2P | TRAP1 11/4885HSP90B1 4/4885MAOB 2890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.