SCHEMBL6971932

SCHEMBL6971932

CN(C)c1ccc(N)cc1CNC(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
GAA P10253 2/20 0.40
MAPK1 P28482 1/20 0.40
EPHX2 P34913 1/20 0.38
NR1H4 Q96RI1 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
TSHR P16473 2/20 0.37
PRKCI P41743 1/20 0.37
CYP2D6 P10635 1/20 0.37
ACHE P22303 2/20 0.36
PPIB P23284 1/20 0.35
ALDH1A1 P00352 3/20 0.34
HPGD P15428 3/20 0.34
KDM4E B2RXH2 2/20 0.34
LMNA P02545 2/20 0.33
ALOX15 P16050 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2181531 0.85 NPC1 (0.46) GAAKMT2AALDH1A1HPGDKDM4E
SCHEMBL6281581 0.82 KDM4A (0.41) EPHX2NR1H4
SCHEMBL27404729 0.79 MAPT (0.41) MAPTGAAMAPK1KMT2ACYP2C9
SCHEMBL6978105 0.78 ALDH1A1 (0.57) MAPTGAAKMT2ACYP1A2CYP2C9
SCHEMBL150471 0.77 PRKCI (0.44) MAPTGAAMAPK1KMT2ATSHR
SCHEMBL792020 0.75 PRKCI (0.43) MAPTGAAMAPK1KMT2ATSHR
SCHEMBL27787353 0.75 AKR1B1 (0.44) EPHX2NR1H4KMT2ACYP1A2CYP2C9
SCHEMBL16291006 0.75 EPHX2 (0.47) MAPTGAAEPHX2NR1H4KMT2A
SCHEMBL395408 0.74 NR1H4 (0.47) MAPTGAAEPHX2NR1H4KMT2A
SCHEMBL4532794 0.73 SLC6A4 (0.47) MAPTGAAMAPK1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1169316-B9 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOD CONSEILS RECH APPLIC (FR) 2003-10-29 EP disclosed
US-6605637-B1 Nitrogen monoxide synthase inhibitors; such as n-(4-(((2-thienyl)(imino)methyl)amino)phenyl)-1,2-dithiolane-3-pentamide SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2003-08-12 US disclosed
EP-1169316-B1 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOD CONSEILS RECH APPLIC (FR) 2003-03-05 EP disclosed
CN-1349523-A Novel lipoic acid derivatives, their prepn., and pharmaceutical compositions containing them CONSEIL DE RECH S ET D APPLIC (FR) 2002-05-15 CN disclosed
EP-1169316-A1 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-01-09 EP disclosed
WO-2000059899-A1 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEIL DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-10-12 WO disclosed