Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962291 | 1.00 | NPC1 (0.60) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL6962284 | 0.92 | NPC1 (0.59) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL6967911 | 0.92 | NPC1 (0.59) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL1300384 | 0.91 | NPC1 (0.52) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL6973817 | 0.90 | POLB (0.53) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL6968562 | 0.90 | POLB (0.53) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL21820359 | 0.84 | RAB9A (0.46) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL224352 | 0.81 | DAO (0.41) | SMN1; SMN2KMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL13766444 | 0.81 | PLK1 (0.45) | NPC1RAB9ACYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL6960067 | 0.79 | MEN1 (0.56) | RAB9ASMN1; SMN2CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |