Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.77 |
| ▸ | HTR7 | P34969 | 6/20 | 0.77 |
| ▸ | HTR1A | P08908 | 4/20 | 0.77 |
| ▸ | HTR1D | P28221 | 4/20 | 0.77 |
| ▸ | HTR1B | P28222 | 4/20 | 0.77 |
| ▸ | HTR1F | P30939 | 4/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443507 | 0.87 | HTR6 (1.00) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5767433 | 0.86 | HTR6 (0.58) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL24877919 | 0.85 | HTR6 (0.76) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL30485872 | 0.85 | HTR6 (0.76) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL5497004 | 0.84 | HTR6 (1.00) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL30485865 | 0.84 | HTR6 (1.00) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL6820240 | 0.81 | HTR6 (0.52) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL7429747 | 0.81 | HTR6 (0.77) | HTR6HTR7HTR1AHTR1DHTR1B | |
| SCHEMBL6968868 | 0.80 | HTR6 (0.50) | HTR6HTR7HTR1AHTR1DHTR1B | |
| Oxalic Acid SCHEMBL9597834 | 0.78 | HTR6 (0.64) | HTR6HTR7HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |
| EP-0944595-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023587-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-04 | — | — | WO | disclosed |