Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 11/20 | 0.48 |
| ▸ | CSF1R | P07333 | 7/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | BCR | P11274 | 4/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976381 | 0.99 | HPGDS (0.54) | HPGDSKITCSF1RDDR1ABL1 | |
| SCHEMBL6968978 | 0.94 | MAPK14 (0.54) | HPGDSBRAFMAPK14RAF1 | |
| SCHEMBL6978092 | 0.92 | MAPK14 (0.54) | HPGDSBRAFMAPK14RAF1 | |
| SCHEMBL6968114 | 0.92 | HPGDS (0.50) | HPGDSKITCSF1RDDR1ABL1 | |
| SCHEMBL6973537 | 0.90 | HPGDS (0.62) | HPGDSKITCSF1RDDR1ABL1 | |
| SCHEMBL6979840 | 0.89 | HPGDS (0.61) | HPGDSKITCSF1RDDR1ABL1 | |
| SCHEMBL6974176 | 0.84 | MAPK14 (0.54) | KITCSF1RDDR1ABL1BRAF | |
| SCHEMBL6968243 | 0.83 | MAPK14 (0.61) | HPGDSBRAFMAPK14RAF1 | |
| SCHEMBL6980722 | 0.82 | MAPK14 (0.65) | HPGDSBRAFMAPK14RAF1 | |
| SCHEMBL31721214 | 0.82 | HPGDS (0.65) | HPGDSKITCSF1RDDR1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |