Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22301206 | 1.00 | KCNH2 (0.55) | KCNH2MAPTHRH3LMNAALDH1A1 | |
| SCHEMBL6950591 | 0.94 | MAPT (0.55) | KCNH2MAPTHRH3LMNAALDH1A1 | |
| SCHEMBL27883912 | 0.89 | KCNH2 (0.54) | KCNH2MAPTHRH3LMNAALDH1A1 | |
| SCHEMBL4172495 | 0.87 | MAPT (0.58) | KCNH2MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL15569388 | 0.87 | MAPT (0.62) | KCNH2MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9492378 | 0.86 | KCNH2 (0.56) | KCNH2GNAI3GNAO1GNAI1 | |
| SCHEMBL9493390 | 0.86 | KCNH2 (0.56) | KCNH2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL5071255 | 0.85 | MAPT (0.57) | KCNH2MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL17598265 | 0.85 | MAPT (0.54) | KCNH2MAPTHRH3LMNAALDH1A1 | |
| SCHEMBL8316368 | 0.84 | HRH3 (0.58) | KCNH2MAPTHRH3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | disclosed |
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |