Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.53 |
| ▸ | BRS3 | P32247 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MGAT3 | Q09327 | 5/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264391 | 0.84 | KMT2A (0.54) | KMT2ANPC1SIGMAR1ABCB1ABCC1 | |
| SCHEMBL6962490 | 0.83 | KMT2A (0.56) | KMT2ANPC1MEN1RAB9ANR1H2 | |
| SCHEMBL6968803 | 0.81 | KMT2A (0.58) | KMT2ANPC1ABCB1ABCC1MEN1 | |
| SCHEMBL6968137 | 0.81 | NPC1 (0.53) | KMT2ANPC1ABCB1ABCC1MEN1 | |
| SCHEMBL6966787 | 0.80 | KMT2A (0.60) | KMT2ANPC1SIGMAR1BRS3MEN1 | |
| SCHEMBL6971135 | 0.78 | SIGMAR1 (0.66) | KMT2ASIGMAR1ABCB1ABCC1TAAR1 | |
| SCHEMBL6974709 | 0.77 | NPC1 (0.57) | KMT2ANPC1ABCB1ABCC1MEN1 | |
| SCHEMBL6970730 | 0.77 | NPC1 (0.53) | KMT2ANPC1ABCB1ABCC1MEN1 | |
| SCHEMBL6965569 | 0.77 | NPC1 (0.53) | KMT2ANPC1ABCB1ABCC1MEN1 | |
| SCHEMBL11455526 | 0.76 | KMT2A (0.66) | KMT2ANPC1SIGMAR1ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |