Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | MMP9 | P14780 | 7/20 | 0.35 |
| ▸ | MMP13 | P45452 | 7/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 3/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435224 | 0.82 | CYP3A4 (0.48) | MMP2MMP9MMP13MMP3MMP8 | |
| SCHEMBL17318235 | 0.81 | KMT2A (0.31) | KMT2A | |
| SCHEMBL6963483 | 0.79 | — | — | |
| SCHEMBL5717299 | 0.79 | USP2 (0.36) | MMP2MMP9MMP13MMP14PKM | |
| SCHEMBL6272775 | 0.76 | — | — | |
| SCHEMBL222005 | 0.73 | CYP2D6 (0.49) | MMP2MMP9MMP13MMP3MMP8 | |
| SCHEMBL6097362 | 0.71 | SMN1; SMN2 (0.56) | MMP2MMP13CYP2C19TSHRKMT2A | |
| SCHEMBL5717351 | 0.69 | MMP2 (0.47) | MMP2MMP9MMP13MMP3MMP8 | |
| SCHEMBL5717332 | 0.68 | MEN1 (0.48) | MMP2MMP9MMP13MMP14PKM | |
| SCHEMBL20599686 | 0.67 | KMT2A (0.37) | CYP2C19TSHRKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |