Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | WNT3 | P56703 | 2/20 | 0.44 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274885 | 1.00 | HSD17B10 (0.71) | HSD17B10HRH2HRH1UCHL1SMN1; SMN2 | |
| SCHEMBL13779912 | 1.00 | HSD17B10 (0.71) | HSD17B10HRH2HRH1UCHL1SMN1; SMN2 | |
| SCHEMBL13779915 | 0.96 | HSD17B10 (0.66) | HSD17B10HRH2HRH1UCHL1SMN1; SMN2 | |
| SCHEMBL5219163 | 0.90 | HSD17B10 (0.77) | HSD17B10HRH2HRH1UCHL1HPGD | |
| SCHEMBL3280014 | 0.90 | HSD17B10 (0.77) | HSD17B10HRH2HRH1UCHL1HPGD | |
| SCHEMBL18461898 | 0.90 | HSD17B10 (0.77) | HSD17B10HRH2HRH1UCHL1HPGD | |
| SCHEMBL30065870 | 0.89 | HSD17B10 (0.76) | HSD17B10HRH2HRH1UCHL1SMN1; SMN2 | |
| SCHEMBL3274878 | 0.88 | HSD17B10 (0.75) | HSD17B10HRH2HRH1UCHL1HPGD | |
| SCHEMBL6979623 | 0.88 | HSD17B10 (0.75) | HSD17B10HRH2HRH1UCHL1HPGD | |
| SCHEMBL5429775 | 0.87 | HSD17B10 (0.72) | HSD17B10HRH2HRH1UCHL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |