Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | PREP | P48147 | 1/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274878 | 1.00 | HSD17B10 (0.75) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL18461898 | 0.98 | HSD17B10 (0.77) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL5219163 | 0.98 | HSD17B10 (0.77) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL3280014 | 0.98 | HSD17B10 (0.77) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL5429775 | 0.95 | HSD17B10 (0.72) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL5429769 | 0.95 | HSD17B10 (0.72) | HSD17B10HPGDPREPUCHL1HRH2 | |
| SCHEMBL13779912 | 0.88 | HSD17B10 (0.71) | HSD17B10HPGDUCHL1HRH2HRH1 | |
| SCHEMBL6973694 | 0.88 | HSD17B10 (0.71) | HSD17B10HPGDUCHL1HRH2HRH1 | |
| SCHEMBL15014501 | 0.88 | HSD17B10 (0.76) | HSD17B10HPGDUCHL1HRH2HRH1 | |
| SCHEMBL7116177 | 0.88 | HSD17B10 (0.76) | HSD17B10HPGDUCHL1HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313727-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2002016352-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-02-28 | — | — | WO | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |