Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.57 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975779 | 0.96 | MAPK14 (0.58) | MAPK14RAF1BRAFSMOMAPK13 | |
| SCHEMBL7840065 | 0.93 | MAPK14 (0.59) | MAPK14RAF1BRAF | |
| SCHEMBL6533594 | 0.90 | OPRK1 (0.56) | MAPK14RAF1BRAFSMO | |
| SCHEMBL7838250 | 0.89 | MAPK14 (0.60) | MAPK14RAF1BRAF | |
| SCHEMBL6979962 | 0.89 | MAPK14 (0.61) | MAPK14RAF1BRAFSMOMAPK13 | |
| SCHEMBL7835408 | 0.86 | MAPK14 (0.63) | MAPK14RAF1BRAFMAPK13 | |
| SCHEMBL2979241 | 0.86 | OPRK1 (0.55) | MAPK14RAF1BRAFSMO | |
| SCHEMBL7806472 | 0.85 | OPRK1 (0.51) | MAPK14SMO | |
| SCHEMBL6978609 | 0.85 | MAPK14 (0.68) | MAPK14RAF1BRAFSMOMAPK13 | |
| SCHEMBL6476766 | 0.85 | OPRK1 (0.59) | MAPK14RAF1BRAFSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |