Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.36 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.38 |
| ▸ | PRKCG | P05129 | 7/20 | 0.38 |
| ▸ | PRKCB | P05771 | 7/20 | 0.38 |
| ▸ | PRKCA | P17252 | 7/20 | 0.38 |
| ▸ | PRKCH | P24723 | 7/20 | 0.38 |
| ▸ | PRKCI | P41743 | 7/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 7/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.38 |
| ▸ | PRKACA | P17612 | 5/20 | 0.38 |
| ▸ | PRKACG | P22612 | 5/20 | 0.38 |
| ▸ | PRKACB | P22694 | 5/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967301 | 0.97 | PRKD3 (0.40) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6968882 | 0.93 | PRKD3 (0.40) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Sulfuric Acid SCHEMBL6973814 | 0.92 | PRKD3 (0.39) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Sulfuric Acid SCHEMBL6973792 | 0.85 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6970886 | 0.82 | PRKD3 (0.43) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6959978 | 0.77 | KMT2A (0.40) | MEN1KMT2ASMN1; SMN2PKN1PKN2 | |
| Sulfuric Acid SCHEMBL6973799 | 0.77 | PRKD3 (0.42) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6972930 | 0.76 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6974324 | 0.75 | KMT2A (0.40) | MEN1KMT2APKN1PKN2HTT | |
| SCHEMBL6967350 | 0.74 | SMN1; SMN2 (0.44) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |