SCHEMBL6973895

SCHEMBL6973895

NC(=O)C1c2cc[c]cc2CCN1Cc1cccc(S(N)(=O)=O)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
MAPK1 P28482 2/20 0.37
MAPT P10636 1/20 0.37
MMP1 P03956 4/20 0.36
MMP2 P08253 4/20 0.36
MMP9 P14780 4/20 0.36
MMP12 P39900 4/20 0.36
MMP14 P50281 4/20 0.36
MMP15 P51511 4/20 0.36
MMP16 P51512 4/20 0.36
MMP26 Q9NRE1 4/20 0.36
MMP7 P09237 3/20 0.36
NPC1 O15118 1/20 0.34
CA1 P00915 10/20 0.34
CA2 P00918 10/20 0.34
CA9 Q16790 9/20 0.34
CA12 O43570 5/20 0.34
CA4 P22748 4/20 0.33
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965834 0.86 ESR1 (0.39) MMP1MMP2MMP9MMP12MMP14
SCHEMBL6974425 0.85 GBA1 (0.39) ALDH1A1MAPTPRMT5WDR77POLB
SCHEMBL6972567 0.85 MAOB (0.42) ALDH1A1NPC1
SCHEMBL6972456 0.85 KDM4E (0.40) MAPTL3MBTL1
SCHEMBL6966047 0.84 ESR1 (0.37)
SCHEMBL6957504 0.83 SIRT2 (0.44)
SCHEMBL6974038 0.82 ALDH1A1 (0.42) ALDH1A1LMNA
SCHEMBL6971131 0.82 SIRT2 (0.43) ALDH1A1MAPTPOLB
SCHEMBL6967397 0.82 SIRT2 (0.45) ALDH1A1MAPK1MAPTLMNAPOLB
SCHEMBL6960589 0.82 KMT2A (0.45) ALDH1A1MAPTLMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832069-B1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER (US) 2003-03-05 EP disclosed
EP-1181954-A2 Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion PFIZER INC. (US) 2002-02-27 EP disclosed
EP-0832069-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996040640-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1996-12-19 WO disclosed