Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL2169183 | 0.96 | TSHR (0.50) | — | |
| Chloroform SCHEMBL2819782 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL35119 | 0.95 | — | — | |
| Chloroform SCHEMBL7768433 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8192102 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7542887 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8927139 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8927142 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7542885 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8196816 | 0.95 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088507-A1 | ANTIMICROBIAL PHOTOACTIVE NANOFIBROUS POLYMER MATERIAL | LAM-X a.s. (CZ) | 2023-05-25 | — | — | WO | disclosed |
| EP-4179874-A1 | ANTIMICROBIAL PHOTOACTIVE NANOFIBROUS POLYMER MATERIAL | LAM-X a.s. (CZ) | 2023-05-17 | — | — | EP | disclosed |
| EP-0807630-B1 | HETEROCYCLIC COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2003-05-07 | — | — | EP | disclosed |
| EP-0790974-B1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | BAYER AG (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6166082-A | Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors | BAYER CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000064463-A1 | PSYCHOTROPIC POLYGALASAPONINS, AND ITS EXTRACTION AND ISOLATION FROM $i(POLYGALAE RADIX) | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2000-11-02 | — | — | WO | disclosed |
| US-5849757-A | Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| US-5789434-A | ACID, ESTER OR AMIDE DERIVATIVES AS ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS AND REDUCTION OF CARTILAGE DETERIORATION | BAYER CORPORATION (US) | 1998-08-04 | — | — | US | disclosed |
| CN-1179155-A | Heterocyclic compounds | DAIICHI PHARMACEUTICLA CO LTD (JP) | 1998-04-15 | — | — | CN | disclosed |
| WO-1998009964-A1 | IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |
| EP-0807630-A1 | HETEROCYCLIC COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-11-19 | — | — | EP | disclosed |
| EP-0790974-A1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | Bayer Corporation (US) | 1997-08-27 | — | — | EP | disclosed |
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996015096-A1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | BAYER CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |
| US-5441960-A | 1-pyrimidinylacetamide human leukocyte elastate inhibitors | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0636141-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS. | ZENECA LTD (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021210-A1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| US-4959097-A | BRASSINOSTEROIDS, PLANT GROWTH REGULATORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1990-09-25 | — | — | US | disclosed |
| US-4627853-A | Method of producing prostheses for replacement of articular cartilage and prostheses so produced | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1986-12-09 | — | — | US | disclosed |